Karyotype of Prader-Willi syndrome, computer illustration. This is a genetic disorder caused by the deletion of a region on chromosome 15 inherited from a person's father. The deletion of this part of the chromosome causes poor foetal muscle tone, poor genital development and severe mental retardation. Older infants may become obese, and fail to thrive. Support is often necessary throughout life. Labelled version of the illustration.

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