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Type I topoisomerase bound to DNA. Molecular model showing a type I topoisomerase molecule (khaki) bound to a strand of DNA (deoxyribonucleic acid, red and blue). The topoisomerase enzymes assist in uncoiling DNA. DNA is usually stored in a supercoiled form, which must be unravelled before it can be replicated or translated into proteins. Type I topoisomerase changes the linkage in multiples of one, while Type II changes the linkages in steps of two.

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